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Abstracts for Current Projects

Project abstracts are a primary source of information regarding the status and progress for LRI’s currently funded projects. These abstracts are provided each year by the principal investigators as a key part of their research agreement with LRI. Links to abstracts for each of these projects are located at the end of the project titles in the list below. See the ACC Research Catalog to access publications from current and past LRI research projects.

Current LRI Research Project Portfolio: 17

Accelerating Exposure Science for Product Stewardship, Sustainability and Regulatory Decision-Making

Project Title: Expanding and Improving the EAS-E Suite Platform for Exposure Modeling
Principal Investigator: Jon Arnot, Ph.D.
Research Institution: ARC Arnot Research & Consulting Inc.

Project Title: Exposure Research Using Robotics to Measure Concentrations / Verify Exposure Model Predictions
Principal Investigator: Albania Grosso
Research Institution: Lower Olefins and Aromatics REACH Consortium (A.G.) and Stantec (H.L.)

Project Title: Population Life-course Exposure to Health Effects Model (PLETHEM) - Continued Platform Development and Education and Outreach
Principal Investigator: Marjory Moreau, Ph.D. 
Research Institution: ScitoVation

Advancing New Approach Methods (NAMs) for Application in Risk Assessment through Development of Scientific Confidence

Project Title: Using the New ICCVAM NAM Validation Guidance to Evaluate the Threshold of Toxicological Concern as a Computational NAM 
Principal Investigator: Susan Borghoff, Ph.D.; Chadwick M. Thompson, Ph.D, M.B.A 
Research Institution: ToxStrategies

Project Title: Development of a Tiered Approach for the Application of In Vitro to In Vivo Extrapolation (IVIVE) for Developmental Toxicity in Support of New Approach method (NAM)- Based Chemical Safety Assessments
Principal Investigator: Harvey Clewell, Ph.D.  
Research Institution: Ramboll

Project Title: Exploring Tissue Chips for Toxicity Testing: Testing Consortium at Texas A&M University (TEX-VAL)
Principal Investigators: Ivan Rusyn, Ph.D.,; Courtney Sakolish, Ph.D.,; Clifford Stephan Ph.D.
Research Institution: Texas A&M University

Project Title: Development of a Fit-For-Purpose In Vitro Model of Lung Toxicity
Principal Investigator: Les Recio, Ph.D.  
Research Institution: ScitoVation

Project Title: Application of Toxicogenomics in Next-Generation Risk Assessment
Principal Investigator: Rasim Barutcu, Ph.D.
Research Institution: ScitoVation

Project Title: Advancing Respiratory Tract Cell Culture NAM Models for Risk-Based Decision-Making 
Principal Investigator: Joanne Wallace, Ph.D.; Seyoum Ayehunie, Ph.D.
Research Institution: Charles River Laboratories Edinburgh and MatTek

Project Title: Omics for Assessing Signatures for Integrated Safety (OASIS) Consortium
Consortium Manager: Chrissy Crute, Ph.D.
Research Institution: Health and Environmental Sciences Institute (HESI)

Project Title: Developmental Toxicity NAMs Scoping Review Update
Principal Investigators: ACC LRI Strategic Science Team
Research Institution: ACC LRI

Project Title: Developing In Vitro Metabolic Clearance Data to Support Development of the Internal Threshold of Toxicological Concern (iTTC)
Principal Investigator: Sherry Black   
Research Institution: RTI

ACC LRI Focus Area: Strengthening Public Health Science Approaches for Evaluating Co-exposures and Cumulative Impacts in Communities

Project Title: Investigating Dose Addition and Response Addition for Risk Assessment of Mixtures
Principal Investigator: Paul Price, Ph.D.
Research Institution: Risk Sciences International

Project Title: A Comprehensive Review and Appraisal of Frameworks, Methods, Metrics, and Data Used in Assessments of Communities with Environmental Justice Concerns
Principal Investigator: William Rish, Ph.D; Ann Verwiel 
Research Institution: ToxStrategies

Project Title: Evaluating Morphological, Behavioral & Transcriptomic Responses in the Zebrafish Developmental Toxicity Assay to Chemical Mixtures Commonly Associated with Environmental and Human Biomonitoring Studies
Principle Investigator: Robyn Tanguay, Ph.D.
Research Institution: Oregon State University

Project Title: Creating and Sustaining Successful Public-Private Partnerships (PPPs) for Environmental Monitoring Programs: Principles and Elements
Principal Investigator: Judy LaKind, Ph.D. 
Research Institution: LaKind Associates, LLC

Project Title: Exploring Artificial Intelligence Technologies to Develop a “Causal Research Assistant”
Principal Investigator: Tony Cox, Ph.D.
Research Institution: Cox Associates