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Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa

Authors: Rory B. Conolly, Jerry L. Campbell, Harvey J. Clewell, Jeffry Schroeter, Julia S. Kimbell, P. Robinan Gentry

In this work, the authors used computational fluid dynamics (CFD) modeling to predict flux of inhaled (exogenous) formaldehyde (exogF) from air into tissue at the specific locations where DNA adducts were measured. At all concentrations examined, the concentrations of endogenous DNA-protein crosslink (DPX) and exogenous DPX were predicted to be at least 10-fold higher than that of their deoxyguanosine counterparts. The modeled dose-dependent concentrations of these adducts are suitable to be used together with data on the dose-dependence of cell proliferation to conduct quantitative modeling of formaldehyde-induced rat nasal carcinogenicity.