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Threshold of Toxicological Concern (TTC) Q&A Document 

With increasing interest in non-animal alternatives and new approach methodologies (NAMs), a number of researchers in academia, government, and the private sector have increased focus on the potential to use the Threshold of Toxicological Concern (TTC) in tiered risk-based applications for commodity chemicals.

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American Chemistry Council

The American Chemistry Council’s mission is to advocate for the people, policy, and products of chemistry that make the United States the global leader in innovation and manufacturing. To achieve this, we: Champion science-based policy solutions across all levels of government; Drive continuous performance improvement to protect employees and communities through Responsible Care®; Foster the development of sustainability practices throughout ACC member companies; and Communicate authentically with communities about challenges and solutions for a safer, healthier and more sustainable way of life. Our vision is a world made better by chemistry, where people live happier, healthier, and more prosperous lives, safely and sustainably—for generations to come.