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Does occupational exposure to formaldehyde cause hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells?

Authors: Mundt, Kenneth, Alexa Gallagher, Linda Dell, Ethan Natelson, Paolo Boffetta, and Robinan Gentry.

Conducted additional and refined analysis on the key underlying data (including specifically exposure information which had not been previously provided) utilized in a study relied upon in the draft IRIS assessment (e.g. Zhang et al. 2010). The analysis evaluates exposed and unexposed populations and any potential correlations between formaldehyde exposure and aneuploidy among the exposed populations. Results showed that differences in white blood cell, granulocyte, platelet, and red blood cell counts were not exposure-dependent. Additionally, among formaldehyde-exposed workers, no association was observed between individual formaldehyde exposure estimates and frequency of aneuploidy, which the original study authors suggested were indicators of myeloid leukemia risk.

Foundation for Chemistry Research & Initiatives

The Foundation for Chemistry Research and Initiatives (Foundation), is a 501(c)(3) tax-exempt organization established by the American Chemistry Council (ACC). Through partnerships with academia, research institutions, governmental and non-governmental organizations, and private corporations, the Foundation supports scientific research on various chemistries; the development of training programs for the safe use and application of products; and programs demonstrating chemistry’s contribution and benefits to society.

The Foundation was established in 1995 as the Research Foundation for Health and Environmental Effects (RFHEE).