The Center for the Polyurethanes Industry (CPI) prepared this guidance document to provide basic principles to users receiving, unloading and handling Methylene Diphenyl Diisocyanate (MDI) and/or various grades1 in a variety of packagings. This document summarizes some, but not all, U.S. Department of Transportation (DOT) regulatory requirements and industry best practices regarding receiving, unloading and handling of MDI. These guidelines should not be interpreted in a manner that might conflict with existing international, national, state or local laws and regulations. Standards, laws, and requirements can change and have precedence over these guidelines. Consult with appropriate legal counsel to verify applicable standard and requirements.